DOI: 10.36347/sjmcr.2022.v10i02.002

Pages: 55-58

Introduction: A unique white cell abnormality called transient abnormal myelopoiesis [TAM] is found in approximately 10% of neonates with Down’s syndrome. Material & method: Medical record of a case of confirmed TAM in Down’s syndrome was reviewed in retrospect at Desai Metropolis laboratory. The co-relation of prenatal ultrasonographic findings, maternal screen results, fetal blood analysis, flow cytometry, karyotyping and the postnatal clinical course were done. Result: A case of TAM associated with Down’s syndrome was confirmed in November 2021. A complete blood count done on 2nd day of life showed abnormal leukocytosis with blast cells. TAM spontaneously resolved after 15 days of birth. Conclusion: Fetal TAM is a self-limiting condition which requires supportive care. In the neonatal period, most cases of TAM have a favorable outcome from this preleukemic condition, but some progress to leukemia. Investigation of TAM will continue to strongly influence basic and clinical research into development of hematological malignancies.