DOI: 10.21276/sasjs.2019.5.2.5

Pages: 91-103

Irvingia gabonensis is an African tree with edible yellow fruit resembling mangoes valued for its oil rich seed,fresh fruit, fuel, fibre, medicine,and hardy green termite resistant wood.this study was undertaken to investigate the effects of Irvingia gabonensis seed extract on the gastric microstructure of adult wistar rats. Thirty-five adult albino rats were used for this experiment. The rats were divided into seven different groups with 5 rats in each group. Group a (control group) was treated with distilled water. Group B1, B2, C1, C2, D1 and D2 (experimental groups) was treated with 0.85ml, 2.55ml, 0.80ml, 2.70ml, 0.90 ml and 2.55ml/kg body weight of Irvingia gabonensis seeds extract respectively, once daily for 21 days. The weight of the animals was taken once a week and the data were analyzed using descriptive statistical tool the doses for the extract were calculated from the lethal dose (LD50) experiment conducted for dose determination. At the end of the administration, the stomachs were harvested from each group after animal sacrifice, processed and stained using hematoxylin and eosin staining technique. Histological findings revealed that group a showed normal stomach features, group B1and B2 treated with 0.85ml and 2.55ml of the raw ground extract in water showed inflammation of the mucous secreting cells and mildly erythematous mucosa. Group C1 and C2 administered 0.80ml and 2.70ml of the ethanolic extract showed a variant from the normal mucosa revealing a granular mucosa,