DOI: 10.36347/sasjs.2022.v08i03.013

Pages: 134-142

Background: Carcinoma of the breast is the most common female cancer and its incidence is rapidly increasing over the last few decades. In Bangladesh, breast cancer is an issue of gaining concern. Receptor status and histological grade are two important prognostic factors of carcinoma breast. Aim of the study: To assess the relation and distribution of receptor status and tumor grade among pre and postmenopausal patients of carcinoma breast. Methods: This cross-sectional observational study was carried out in the Department of General Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka over a period of one year, a total of 59 admitted female patients with histologically proven carcinoma of the breast were divided into two groups included in this study. The premenopausal age group was considered as a group I (n=31) and the postmenopausal age group was considered as group II (n=28). Data regarding the tumor histopathological type, grading, and receptor status along with other variables were included in a pre-designed data collection sheet. After compiling data, Statistical analyses of the data were done with Statistical Packages for Social Sciences (SPSS- 22). Results: Sociodemographic variables and personal histories leading to a risk of breast cancer have no significant difference between pre and postmenopausal groups. Invasive ductal carcinoma (grade-II) was predominant in both groups. Estrogen and progesterone receptor-negative tumors were more frequent in premenopausal patients and estrogen and progesterone receptor-positive tumors were more frequent in a postmenopausal patient, but no statistically significant difference between the two groups. More than eighty percent of tumors were human epidermal growth factor-2 negative in both groups. The frequency of estrogen and progesterone receptor positivity gradually reduce from grade I to III in both groups and the frequency of estrogen and progesterone receptor negativity gradually increase from grade