DOI: 10.36347/sasjm.2022.v08i03.017

Pages: 197-202

Background: During pregnancy, maternal metabolic environment is modified by a rise in serum levels of estrogen and progesterone, pancreatic beta-cell hyperplasia and an increase in the secretion of insulin. Hyperinsulinemia leads to an increase in peripheral glucose utilization, a decline in fasting plasma glucose levels, increased tissue storage of glycogen, increased storage of fats and decreased lipolysis. The aim of our current study to investigate the changes in lipid profile, blood glucose and blood pressure throughout three trimesters in pregnant ladies. Materials and Methods: This is a hospital based, descriptive analytical cross-sectional study, performed at refer clinic of Omdurman Maternity hospital in Khartoum state. Included 150 apparently healthy pregnant ladies in the study group and 40 healthy non-pregnant ladies as a control group. Anthropometric measurements and blood pressure were measured and blood sample was obtained to analyzed lipid profile and blood glucose. Results: Data analysis showed that the mean level of triglyceride tend to change from slight increase in first trimester and significant increase in the second and third trimester. While mean level of HDL tend to change from slight decrease in the first and second trimester to significant decrease in the third trimester. Whereas there was an increase in both total cholesterol and LDL but was not significant. The mean level of fasting blood glucose was significantly raised in third trimester compared to other first and second Trimesters. Both component of blood pressure was significantly elevated in the first and third trimesters compare to second trimester. Conclusion: Normal pregnancy is associated with dyslipidemic changes due to elevated pregnancy related hormones. Increased insulin resistance leads to production of dyslipidemic changes in mother in form of elevated TG, total cholesterol, LDL and decreased HDL in serum and increased random blood glucose.