DOI: 10.36347/sjams.2022.v10i04.017

Pages: 536-542

Background: Tumor lysis syndrome (TLS) is the combination of metabolic and electrolyte abnormalities (hyperuricemia, hyperkalaemia, hyperphosphatemia, and secondary hypocalcemia) which occurs in patients with cancer spontaneously and usually after the initiation of cytotoxic treatment and it can cause serious clinical complications like acute kidney injury and cardiac arrest. Aim of the study: The aim of the study was to identify the associated risk factors of tumor lysis syndrome (TLS) in patients with Acute Lymphoblastic Leukemia (ALL) in a tertiary care hospital. Methods: This cross-sectional study was conducted by Department of Hematology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh October 2019 to September 2020. Newly diagnosed case of Acute Lymphoblastic Leukemia patients admitted in the department of Hematology in BSMMU, Dhaka during the study period. The study was approved by the local ethical committee and all patients gave their informed consent to take part in this investigation. Data were compiled and analyzed using the Statistical Program for Social Science (SPSS-21) version, and organized by using MS-Excel 2016. Results: TLS was absent in 34 and present in 17 cases. Within 3 days before chemotherapy, Hyperuricemia (>8.0 mg/dl) was found in 12(70.59%) cases and was absent in 1(2.33%) cases. Within 7 days after initiation of induction chemotherapy, Hyperuricemia (>8.0 mg/dl) was seen in 13(76.47%) cases. 12(70.59%) respondents were <20 years who were with TLS and 23(53.49%) case were not with TLS and followed by 7(41.18%) cases with TLS were from ≥20 years and 20(46.51%) were not with TLS. B cell type with TLS was found in 7(41.18%) and without TLS was 33 (76.74%) cases and followed by T cell type in 10(58.82%) cases and 10(23.26%) case. Initial WBC count (>50.0 x109/L) OR was 2.12 where 95% CI was lower in 0.91 and upper in 7.16. S. LDH (≥1000 U/L) OR was 13.07 and 95% CI was lower in 1.93 and upper in 101.23. Conclusion: In this ...