DOI: 10.21276/sasjs.2019.5.7.8

Pages: 301-307

Despite the high standards of sterilization post operative surgical site infection is common. Single dose of prophylactic antibiotic at the time of induction of anesthesia could brought down the incidence of wound infection considerably .Our aim of study were to assess the efficacy of single dose of commonly used broad spectrum antibiotics in clean and clean contaminated cases in prevention of postoperative wound infection. Total 125 patients divided into five groups are selected for study between May 2017 to October 2018 in surgical ward of Mahatma Gandhi hospital Jaipur India. All groups except one given single dose of antibiotic at the time of induction of anesthesia .In all five groups, postoperative evaluation of the wound was done & any discharge from the wound was sent for bacteriological culture and sensitivity testing. Post operative surgical site infection rates were compared. Current study did not demonstrate a difference in the rate of infection between patients receiving preoperative antibiotics alone (1.56%) versus those receiving preoperative followed by postoperative multiple doses of antibiotics (1.20%, P = 0.711). Only a single dose of antibiotic administered at the time of induction of anesthesia is able to prevent post operative wound infection efficiently and minimize side effects and hospital expenditures.