DOI: 10.36347/sjams.2022.v10i04.031

Pages: 614-622

Background: Diabetic nephropathy is a kidney disease associated with long-standing hyperglycemia. The main features of diabetic nephropathy include nephrotic syndrome with excessive filtration of protein into the urine (proteinuria), high blood pressure (hypertension), and progressive impairment of kidney function. Objective: To find out the clinical utility of urinary β2 microglobulin in the detection of early nephropathy in type 2 diabetes mellitus patients. Methods: This cross-sectional study was conducted in the Department of Nephrology, Dhaka Medical College Hospital, over a period of one year from January 2017 to December 2017. 50 type 2 diabetes mellitus patients as the case group and age sex-matched 50 healthy participants as the control group was included in this study as the study population. Socio-demographic, family history, history of patients, and epidemiological data were recorded. A clinical examination investigation was done for all the study population. The urinary β2 microglobulin (β2m) level was assayed using the beta- 2- macroglobulin ELISA kit, EIA 3609. Statistical analysis was done by the Statistical Package for Social Science (SPSS-22). The confidence interval was considered at the 95% level. The sensitivity and specificity of urinary β2m were calculated in detecting early DN. P-value <0.05 was considered statistically significant. Result: Mean age of the case group was 50.08±12.06 years and the control group was 46.54±9.89 years. Female was predominant in both case and control group. Hypertension, anemia, diabetic nephropathy, and diabetic peripheral neuropathy were found in 24(48%), 17(34%0, 14(28%), and 11(22%) cases. Urinary ACR was found significantly higher in the case group than that of the control group (183.32±164.11 mg/gm vs 13.60±4.40 mg/gm). Similarly, urinary β2 microglobulin was found significantly higher in the case group than in the control group (0.50±0.22 µgm/ml vs 0.14±0.05 µgm/ml). Among early nephropathy patients .....