DOI: 10.36347/sjams.2022.v10i05.004

Pages: 691-697

Background: Thalassemia is the most common single gene hereditary disease worldwide. Hb E-β Thalassemia is the commonest severe form of thalassemia in south-east Asia including Bangladesh. The clinical benefit of increased Hb-F in thalassemia treatment is well established which act by decreasing the imbalance between β& non- β chains and the consequent reduction of haemolysis. Recent study showed outstanding results on haemoglobin level and transfusion requirement in thalassemia patients treated with thalidomide. Objectives: Aims of our study is to evaluation of thalidomide in spleen size reduction of transfusion dependent thalassemia. Methods and Materials: In this quasi-experimental study 50 patients >12 years old attended in Thalassemia clinic, Department of Haematology, Dhaka Medical College & Hospital, Dhaka were recorded as study cases. All relevant collected prospectively from patients and recorded in prescribed form (Data collection sheet).After full explanation, informed written consent were taken from the selected patients informing the details of the purpose of the study. Data processed and analyzed with the help of computer programme SPSS (Statistical package for social sciences) win version 25& presented in the form of tables, graphs & chart. Results: In study cases it was found that there were significant increment of Hb, Hematocrit, HbF% and improvement of performance status 6months after thalidomide therapy (mean 6.36 ±0.78 vs 7.49±0.59, 19.89±2.57 vs 25.88±2.47, 23.03±14.61% vs 39.42±13.31% and 2.24±0.43 vs 1.50±0.54; respectively; all p <0.001). It also reveledthat after 6 months of thalidomide therapy there were significant reduction of transfusion requirement, spleen size, nRBC count, Serum LDH, Serum Bilirubin (total) and Serum ferritin (100.06±27.2 vs 54.48±18.34 ml/kg/year, 12.3±6.73 vs 9.28±5.26 cm, 42.28±61.02 vs 16.96±30.14nRBC/100 WBC, 502.60±124.54 vs 413.28±152.43 U/L, 3.00±1.36 vs 2.12±0.78 mg/dl, 2235.3±2225.6 vs 1574.9±1540.7; .......