DOI: 10.36347/sjams.2022.v10i05.020

Pages: 793-797

This study was designed to evaluate the effect of hydro-methanol leaf extract of Eugenia uniflora on lead-induced reproductive toxicity in male Wistar rats. The male rats used for the study were divided into 5 groups of 6 animals each. Group I was the negative control group which received no treatment. Group II was the positive control which received 5 mg/kg BW Lead daily, while Group III received 5 mg/kg BW of Lead and 200mg/kg BW of extract., Group IV received 5 mg/kg BW of Lead and 400mg/kg BW of extract and group V received 5 mg/kg BW of Lead and 800mg/kg BW of extract. The administration was by oral gavage once daily for 30 days. At the end, animals were sacrificed under light chloroform anesthesia. Blood samples were collected into plain bottles for hormonal assay. The epidydimis was located with a small incision on the abdomen and semen sample was collected for analysis of sperm parameters. The data was analysed by applying one-way analysis of variance (ANOVA) using the SPSS version 23 software. Results of this study showed that extract of Eugenia uniflora significantly increased the level of serum testosterone and the percentages of viable sperm cells, sperm cells with normal morphology and actively motile sperm cells as well as, sperm count. The extract ameliorated lead induced reproductive toxicity. The result therefore, show that the extract improves sperm quality and quantity and protects the male reproductive function from the hazardous effect of environmental toxicants such as lead.