DOI: 10.36347/SASJS.2019.v05i10.001

Pages: 377-383

Introduction: Progesterone receptor and Bcl-2 expression were evaluated in endometrial hyperplasia and endometrial carcinoma in this study. Objective/aim: Bcl-2 expression in endometrial carcinoma is regulated in a hormone dependent manner. Bcl-2 expression and progesterone receptor are focal and less intense in atypical hyperplasia and carcinoma than proliferative endometrium and hyperplasia (without atypia). Bcl-2 expression is positively correlated with progesterone receptor in normal and hyperplastic endometrium and well differentiated carcinoma. Methods and material: We evaluated 10 simple, 10 complexes (without atypia), 1 complex (with atypia) hyperplasia and 25 endometrial adenocarcinoma at Ankara Training and Research Hospital. At these cases, we searched Bcl-2 expression and progesterone receptor and evaluated the correlation of these two markers. In endometrial hyperplasia Bcl-2 expression and progesterone receptor were higher than those seen in endometrial carcinoma. At an atypical hyperplasia case, the two markers were negative.