DOI: 10.36347/sjams.2022.v10i06.004

Pages: 882-889

The objective of this study was to identify the potential of salvia hispanica as protective and therapeutic agent against Alzheimer’s disease. The learning and memory enhancing activity of saliva hispanica seed extract were investigated in rats by using the ethanol induced cognitive impairment and diazepam induced amnesia and its effects on learning and memory were examined by using Morris water maze (MWM) test and 8-radial arm maze (8-RAM) test. For Morris water maze test all groups showed significantly (P value is < 0.01 &< 0.05) decreases transfer latency time at all periods as compared to ethanol and diazepam inducing group & for radial arm maze test all groups showed significantly (P value is< 0.0001) decreased in the time taken to reach the paired arm and number of entries in baited arm and non-baited arm as compared to ethanol inducing group. Therefore seed extracts of salvia hispanica exhibited significantly learning and memory activity in Alzheimer’s disease.