DOI: 10.36347/sjmcr.2022.v10i06.027

Pages: 601-603

Intrahepatic cholestasis as a paraneoplastic manifestation is an unusual phenomenon in Hodgkin's lymphoma (HL) which presents both a diagnostic problem because it must be considered after excluding all other causes of cholestasis, and a therapeutic one because the decision and timing of treatment places the clinician in a balance between the hepatotoxicity of chemotherapy and the progression of the lymphomatous disease. We report the case of a 71-years-old patient presenting with cholestatic jaundice and a significant weight loss, whose morphological and anatomopathological explorations concluded to the diagnosis of Hodgkin's lymphoma without lymphomatous infiltration of the liver, associated with idiopathic intrahepatic cholestasis without ductopenia. Low-dose chemotherapy led to clinical and biological improvement of the cholestasis.