DOI: 10.36347/sjams.2013.v01i01.002

Pages: 5-8

Abstract – The present study was undertaken to evaluate the analgesic and antipyretic activities of ethanolic extract of Terminalia pallida Linn. (EETP) stems in experimental animal models. The study was carried out using Albino mice (20-30g) and rats (150-170 g) of either sex. The EETP was prepared by Soxhlet extraction process. The analgesic activity of Terminalia pallida Linn was assessed by using hot plate method and acetic acid induced writhing in mice. The antipyretic activity was assessed by Brewer’s yeast-induced pyrexia in rats. Doses of ethanolic extract of Terminalia pallida used for the present study were 250mg/kg and 500mg/kg. EETP produced a significant decrease in the number of writhes in acetic acid induced writhing model of pain as well as showed a significant increase in the mean reaction time to heat stimuli in hot plate method at both 250mg/kg and 500mg/kg, p.o. doses. Single administration of EETP at doses 250mg/kg and 500mg/kg, p.o. showed significant antipyretic activity throughout the observation period of 3 hours, which was comparable to the standard paracetamol group. The present study suggested that ethanolic extract of Terminalia pallida Linn. has significant analgesic and antipyretic activities.