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Scholars Journal of Applied Medical Sciences | Volume-1 | Issue-01
Synthesis, characterization and evaluation of anti-epileptic activity of four new 2- pyrazoline derivatives compounds
B.Maruthi Rao, Saarangi Ramesh, Dipankar Bardalai, Habibur Rahman, Hamid Ali Shaik
Published: Feb. 28, 2013 |
120
79
DOI: 10.36347/sjams.2013.v01i01.006
Pages: 20-27
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Abstract
Abstract – Two varieties of acetophenones were condensed with two varieties of aromatic benzaldehydes dto get four chalcone derivatives. They undergo condensation followed by cyclisation with isoniazid to get the final four 2-pyrazoline derivatives. The synthesized compounds were characterized by IR, 1H-NMR and mass spectral studies. The synthesized compounds were evaluated for their antiepileptic activity by two methods. The compounds exhibited good antiepileptic activity when compared to the standards.