DOI: 10.36347/sjams.2013.v01i03.002

Pages: 142-146

Abstract: In the present study, protective efficacy of docosahexaenoic acid (DHA) on Aluminum (Al) induced neuronal death were tested. This mode of administration induces caspase -3 and Bax activation along with increased rate of ROS production and release of LDH. Morphologically increased astrocytosis were observed. Coadministration of DHA inhibited caspase-3 and bax expression and abolish ROS. Furthermore, treatment with DHA dramatically inhibits apoptosis, as assessed by the transmission electron microscope as reduced rate of astrocytosis.Treatment with DHA may represent a therapeutic strategy to reverse the neuronal death associatedwith aluminum toxicity and may exert its effect on apoptosis-regulatory proteins.