DOI: 10.36347/sjams.2013.v01i03.011

Pages: 205-208

Abstract: The activities of the enzyme acetylhydrolase was studied in urine samples of diabetics and observed to exacerbate diabetic conditions. Acetylhydrolase catabolizes Platelet Activating Factor (PAF) produced by the kidneys by deactivation. Making use of radioimmunoassay technique to evaluate activities in urine samples from non diabetics and diabetics, activity of the enzyme was detected in normal urine with a mean of ±2D = 0.66 nmol/30min/ml. Higher values were however observed among diabetics, specifically relating raised hydrolase activity to this dysfunctional metabolic state in diabetes mellitus.