DOI: 10.36347/sjams.2016.v04i01.003

Pages: 9-14

Abstract: To compare the efficacy and safety of two (25mcg/4hourly vs 50mcg/8hourly) regimens of intravaginal misoprostol for induction of labour. Settings & Design- It was a prospective comparative randomized study conducted at JLN Hospital & Research Centre, Bhilai, Chhattisgarh. Statically Analysis- Averaged data were reported as mean and standard deviation. Categorical variables were analyzed by chi square test or Fisher exact test and continuous variables by student t-test by using SSPS 14. Methods & Material- 200 eligible pregnant women, admitted for induction of labour were randomly assigned to receive either 25µcg intravaginal misoprostol 4 hourly (group A) or 50 µcg intravaginal misoprostol 8 hourly to a maximum up to 150 µcg and oxytocin augmentation, if needed. Result- Mean induction delivery interval was similar (9.676 hours in group A vs 9.2028 hours in group B). Although there were no difference in mode of delivery among two groups but caesarean for non assuring foetal heart rate and meconium is more in group B whereas it is more for failed induction and non progress of labour in group A. There is significantly more incidences of tachysystole and uterine hyper stimulation in group B (P value <0.039). In Conclusion-25 mcg intravaginal misoprostol 4 hourly is more prudent choice for induction of labour as 50 mcg intravaginal misoprostol 8 hourly is associated with more chances of uterine hyper stimulation and tachysystole without significant difference in mode of delivery, induction delivery interval and early neonatal outcome.