DOI: 10.36347/sjams.2016.v04i01.008

Pages: 34-40

Abstract: Coronary Artery Disease (CAD) is one of the leading cause of death ranked “FIRST” worldwide among the eight killer diseases. Atherosclerosis is the hallmark of CAD. Oxidative stress induced by reactive oxygen species (ROS) is implicated in the pathogenesis of atherosclerosis. LDL oxidation is a potent trigger for the pathological events leading to CAD. Keeping this in view, present study is undertaken to assess the risk of CAD in patients using serum ceruloplasmin and uric acid as biomarkers. The study group consisted of 110 subjects of age group 20-50 years and of both sexes. Of these, 70 were CAD patients (Group 2), and 40 were healthy age and sex matched controls (Group 1). The serum levels of both ceruloplasmin and uric acid are elevated in cases (CAD patients) when compared to controls. The increase is statistically highly significant (p < 0.001). Very large positive correlation was obtained for between ceruloplasmin and uric acid values. Both the parameters also achieved positive correlation with blood glucose and lipid profile parameters with exception of HDL cholesterol which showed negative correlation. Thus Ceruloplasmin and Uric acid levels can be used as biomarkers in the assessment of CAD.