DOI: 10.36347/sjams.2016.v04i01.015

Pages: 81-84

Abstract: Dengue is an acute, infectious, commonest arboviral disease caused by Dengue virus and is endemic in more than 100 countries in tropical and sub tropical region. Hepatic dysfunction is common in dengue infection and the degree of liver dysfunction in adults varies from mild injury with elevation of transaminases to severe injury with jaundice. This study was under taken to assess the spectrum of hepatic involvement in dengue infection. A total of 88 serologically confirmed cases of dengue infection (IgM ELISA) were enrolled. The liver function tests (serum bilirubin, AST, ALT, ALP, serum albumin) were done by using semi automated chemistry analyzer (ERBA). The Mean (±SD) of Total bilirubin, Alanine amino transferase (ALT), Aspartate amino transferase (AST), Alkaline phosphatase (ALP) and serum Albumin values were 1.12±0.14mg/dl, 204.5±11.8 U/L, 362.78±37.8 U/L, 131.7±3.62U/L, 3.13±0.24 g/dl respectively. The mean value of AST was significantly higher than ALT. This study shown that liver injury is common in adult patients with dengue infection. We conclude that Adult dengue patients commonly showed abnormal liver function tests and accounted for at least two-thirds of them. High AST may serve as an early indicator of dengue infection. High serum bilirubin, Alanine amino transferase (ALT), Alkaline phosphatase (ALP) may act as poor prognostic markers.