DOI: 10.36347/sjams.2013.v01i04.004

Pages: 239-244

The aim of this study was to evaluate prevalence and risk factors of oral candidiasis (OC) in patients attended tertiary hospital in Dehradun, India. A total of 130 patients with oral lesions attended tertiary hospital in Dehradun, India between January 2011 and July 2011 were evaluated. Patients were subgrouped as Group 1: HIV seronegative (n=111) and Group 2: HIV-infected (n=19). Ten clinical and laboratorial variables were registered. Univariate analyses were performed on all variables. Out of 130 patients, 70.0% were candida culture positive. Among group 1, 65.8% patients were culture positive while 94.7% of group 2 were positive. C. albicans was dominant isolate among group 1 while non-albicans Candida (NAC) were dominant in group 2. Statistically significant association was identified between the gender (male) (p = 0.0240; Odd ratio (OR) = 2.5), the reduced saliva flow rate (p < 0.0001; OR = 106.1), CD4 count < 200 cell/mm3 (p = 0.0041; OR = 10.7), previous antibiotics users (p < 0.0001; OR = 30.1), AIDS (p = 0.0029; OR = 17.3), those did not received HAART (p < 0.0001; OR = 0.05), bronchitic (p = 0.0013; OR = 0.2), and gutka (smokeless tobacco) chewers (p < 0.0001; OR = 9.5) with OC. Our results are important for the development of strategies to eliminate these indicators of risk and significantly reduce OC in HIV-infected and non-infected adult patients of Dehradun, India.