DOI: 10.36347/sjams.2013.v01i04.019

Pages: 291-294

Antibiosis history began with the observations made by Sanderson and Roberts on the inhibition of bacterial growth by other organisms, at the end of the XIX Century. Biomedical research in this field advanced importantly during World War II, after the discovery of penicillin by Fleming. Now-a-days the number of antibiotics plays an important role in the society particularly animal and human life. In this case Ampicillin is a beta-lactam Antibiotic that has been extensively to treat different bacterial diseases and controlled since 1961. Antibiotic action is against different types of bacteria like Gram positive or Gram negative bacteria. This is a good anti-biotic to the animals and human to prevent the different microbial diseases. The ability of some bacteria to now produce penicillinase to break down and render penicillin completely useless has come about due to the wide scale use of the drug and has therefore limited the effectiveness of penicillin as a clinical treatment. In order to combat this, scientists have turned to semi-synthetic derivatives of penicillin in the hope that these will have the properties necessary to beat the resistance problem.