DOI: 10.36347/sjams.2013.v01i05.0069

Pages: 653-657

There is increasing evidence suggesting that cytokines abnormalities are involved in the pathogenesis of schizophrenic disorders. The aim of this study was to evaluate the serum levels of interleukin-27 (IL-27) and interleukin-13 (IL-13) in patients with schizophrenia compare to healthy control subjects. In present study the serum IL-27 and IL-13 levels of 38 schizophrenic patients and 32 age and sex matched healthy control subjects using a sandwich ELISA assay was measured. It was found that IL-13 serum level were increased significantly in schizophrenic patients compare to healthy control group (4.32 ± 0.94 vs 2.04 ± 0.17, p<0. 01) and a significant increase in female patients (5.2±5.1) and the healthy females (2.05±.21) (p< 0.01) has found. There was also reported a significant increased in IL-13 on male patients (3.63±2.51) and healthy males (2.03±.144) with (p < 0.01). The findings also have been shown that there is a significant difference between the serum level of interleukin-27 of the patient (171) and healthy) group (231) (p < 0.05). By this study, it can conclude that there is a significant decrease between IL-27 in male schizophrenic patients compare to healthy controls. However a significant increase was found between IL-13 schizophrenic patients when compare with healthy control. A non-significant difference was reported in male and female in IL-13 schizophrenic patients.