DOI: 10.36347/sjams.2013.v01i06.0041

Pages: 830-836

The aim was to detect and compare metabolic syndrome and sub clinical atherosclerosis in HIV patients on ART/ not on ART and normal population.This one year study was done among 100 HIV patients on ART and 100 HIV patients who were not on ART and 200 control subjects. Metabolic syndrome was diagnosed according to the guidelines from the 2001 National Cholesterol Education Program ATP III. Sub clinical atherosclerosis was detected by carotid colour Doppler studies. Metabolic syndrome was found in 15(7.5%) control subjects (group A), 19(19%) HIV cases who were not on ART (group B) and 21(21%) HIV cases on ART (group C). In metabolic syndrome positive persons; BMI was greater in controls (29.82 + 3.86kg/m2) than HIV cases (23.18 + 3.41kg/m2 in group B and 22.08 + 2.44kg/m2 in group C) (P<0.05). Waist circumference in control group (98.20 ±9.06cm) was significantly greater than HIV patients who were on ART (89.23±4.70cm) or without ART (89.74±4.09cm) (P < 0.001). But Waist circumference not differ significantly among HIV cases of both groups (P>0.05). SBP was significantly greater in the control group (128.40 + 8.36mm of Hg) as compared with the HIV groups (P <0.05). HIV positive patients on ART had more SBP (125.23 +8.87mm of Hg) than group B (119.58 +10.34 mm of Hg) (P <0.05). In HIV groups FBG were significantly more than the control group (P <0.05). But value not differ significantly among HIV cases (P>0.05). Triglycerides level were significantly increased in HIV cases than the control group (P<0.001) and also significantly higher in HIV group on ART than without ART (P<0.05). HDL was significantly decreased in HIV cases than healthy controls (p <0.05) and in HIV group on ART than without ART (P<0.05). There were no significant difference between all three groups in carotid intima thickness (P >0.05). In conclusion: Compared with controls, HIV patients had a greater frequency of impaired fasting glucose, plasma triglycerides and HDL. Metabolic syndrome might be ass