DOI: 10.36347/sjams.2013.v01i06.0052

Pages: 881-886

The study is aim at investigating effect of combine extracts of Vernonia amygdalina (V.A) and Moringa oleifera (M.O) on STZ induced kidney damage in experimental rat models. The dried leaves of each plant species were extracted in 80% (V/V) ethanol. Thirty-six male and female rats of Wister strain weighing about 140-180g and divided into 6 groups, each group consisting of 6 rats were used for the investigation. Group 1and 2 represented diabetic control, received placebo. Group 3, 4, 5 and 6 serves as diabetic treated groups and received insulin (5IU/b.w), M.O (500mg/kg), V.A(500mg/kg) and combine M.O/V.A (250mg/kg each) respectively. At the end of the 21days, animals were euthanized under chloroform vapor and sacrificed. Whole blood was collected from them via cardiac puncture. Significant increase (P<0.05) in K+ ,Na+, CL- and Urea concentration in groups treated with VA, MO, and MO/VA compared to DC and closely related to NC and Insulin groups was obsevered. Serum glucose levels showed a significant decrease compared with the DC groups and closely related to NC. In conclusion, Result suggests the synergistic effect of the plants in amelioration of nephrotoxicity associated with diabetes mellitus.