DOI: 10.36347/sjams.2014.v02i02.024

Pages: 592-595

Renal disease is a common cause of death and disability in many countries throughout the world. Renal failure can be classified as acute and chronic depending upon the etiological factors. Chronic kidney disease (CKD) is a common threat to critically ill patients in intensive care units with a mortality rate ranging from 42% to 88%. Treatment methods such as dialysis and transplantation are becoming more effective in life threatening conditions. To assess the coagulation profile level in chronic renal failure patients who are on haemodialysis and comparison was made with age matched controls. Totally 50 members were selected for the study. Among them 25members were chronic renal failure patients (Group A) and 25 members were normal healthy subjects served as controls (Group B). Both the groups were age matched and comparison of coagulation profile was done. Parameters analysed in the study are Platelet count (Pl), Prothrombin time (PT), international normalization ration (INR), Activated Prothrombin time (APTT), Plasma fibrinogen (PF). From our study we concluded that Prothrombin time, INR, Activated Prothrombin time, Plasma fibrinogen level were increased in chronic renal failure patients(Group A) when compared to control (Group B). Platelet count was found be increased in control (Group B) when compared to chronic renal failure patients (Group A). Coagulation profiles has a significant variations in chronic renal failure. This leads to lot of complications such as sepsis, massive tissue repair and obstruction in vascular compartment. Regular monitoring of anticoagulant doses and haemodialysis may minimise the risk of vascular injury.