DOI: 10.36347/sjams.2017.v05i02.003

Pages: 307-318

Spondias mombin is a plant widely used in folkloric medicine. It has lots of potential as a medicinal plant. Most of these potentials are yet to be discovered and its anti-infective property could be maximized either by using it alone or combining it with other plants and conventional antibiotics as a means of combating the problem of antibiotic resistance. The aim of the present work is to investigate the synergistic antimicrobial activity of various concentration of extracts of Spondias mombin and ofloxacin investigate the synergistic antifungal activity of extract of Spondias mombin and fluconazole, compare the antimicrobial and antifungal activity of the various parts of the plant (leaf, bark and stem) and to compare the activity of the aqueous and crude ethyl acetate extracts of Spondias mombim and 30 organisms were used for the research. They include 10 (ten) typed bacterial, 10 (ten) locally isolated bacteria and 10 (ten) locally fungal isolates and the results obtained revealed a higher zone of inhibition against the pathogens tested. The findings from this work suggest that Spondias mombin contain some compounds that can enhance the effect of conventional antibiotics and antifungal agents in inhibiting the growth of pathogens.