DOI: 10.36347/sjams.2022.v10i08.030

Pages: 1351-1355

Background: Thyroid hormone has the major role in the cardiovascular system function and cardiac a As well as to maintain the cardiovascular homeostasis. A slightly change in thyroid status actually affects cardiovascular mortality hemodynamic. The background of this study was to define the prevalence of thyroid dysfunction in acute coronary syndrome (ACS). Objective: To assess thyroid hormonal profile in patients presenting with acute coronary syndromes (ACS). Methods: A hospital based, retrospective, observational comparative study was carried out at the Dept. of Cardiology, Bangabandhu Sheikh Mujib Medical College and Hospital, Faridpur, Bangladesh from January to June 2020. Data of all patients with acute coronary syndrome presenting to hospital were collected in a pre-structured proforma and analyzed. Results: A total of 100 ACS patients between 21 years to 75 years with mean age of 59.23 ± 11.30 years were studied. One hundred and twenty seven (64.0%) were males. Among them 58 (58%) was ST segment elevated myocardial infarction (STEMI) patients while 42 (42%) were unstable angina/ non-ST elevated myocardial infarction (UA/ NSTEMI) patients. Total 23 (23.0%) patients had abnormal TFT of which 14(60.8%) had Euthyroid Sick Syndrome, 6(26.0%) had subclinical hypothyroidism, 3(13.0%) had subclinical hyperthyroidism and 1(4.2%) had low fT4 with normal fT3 and normal TSH. There was significant difference in TFT in patients with STEMI and UA/NSTEMI (P=0.006).There were higher rates of heart failure (p= 0.001 & 0.003 in STEMI & UA/NSTEMI respectively), longer length of hospital stay (3+0.17 days) and high mortality (more than 4 fold) in all types of ACS patients with abnormal TFT than ACS patients with normal TFT. Conclusion: There is higher prevalence of abnormal thyroid hormonal findings in ACS causing significant morbidity and mortality.