DOI: 10.36347/sjams.2014.v02i03.004

Pages: 908-910

The present study was conducted to assess the hepatoprotective activity of ethanolic leaf extract of Polyalthia longifolia against paracetamol induced liver damage in rats. The ethanolic leaf extract of Polyalthia longifolia (400mg/kg) was administered orally to the animals with hepatotic damage induced by paracetamol (3gm/kg). Silymarin (25mg/kg) was given as reference standard. All the test drugs were administered orally by suspending in 0.5% Carboxy methyl cellulose solution. The plant extract was effective in protecting the liver against the injury induced by paracetamol in rats. This was evident from significant decrease in serum enzymes alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and bilirubin. It was concluded from the result that the ethanolic leaf extract of Polyalthia longifolia possesses hepatoprotective activity against paracetamol induced hepato toxic in rats.