DOI: 10.36347/sjams.2014.v02i02.050

Pages: 711-717

Hematological abnormalities are a common complication of HIV infection. Present work was carried out to compare bone marrow abnormalities with peripheral hematological abnormalities in patients with HIV/AIDS. 160 patients of HIV +ve were included in the study. A complete blood count, relevant biochemical investigations, CD4 counts were done, besides a thorough history and clinical examination. HIV positive patients were classified as those having AIDS and those without AIDS according to NACO criteria. Bone marrow examination was performed for indication of anemia, leucopenia, pancytopenia and thrombocytopenia. As per CDC criteria 59.81% patients had AIDS in 107 patients. The most common hematological abnormality was anemia, seen in 93.12% patients. Bone marrow was normocellular in 79.06% of non-AIDS and 79.68% of AIDS, hypocellular in 13.95% of non-AIDS and 12.5% of AIDS, hypercellular in 06.97% of non-AIDS and 07.81 % of AIDS patients. For myelodysplasia in bone marrow in HIV patients we noted granulocytic dysplasia in 4.65% in Non –AIDS and 14.06% AIDS patients. Erythrocytic dysplasia in 9.30% in Non –AIDS, 12.5% in AIDS group. Thrombocytopenia was seen in4 cases of ART (4.93%) and 3 cases (4.68%) of AIDS group. Abnormal cells like plasma cell, histocyte and toxic granule were also found. In conclusion, Myelodysplasia was more common in AIDS than in non AIDS patients. Granulocytic series is most commonly associated with evidence of dysplasia. Anemia in HIV patients can be a good clinical indicator to predict and access the underlying immune status. Thus present study is imperative to methodically observe and follow clinical and laboratory aberration in such patients in order to improve our diagnostic and therapeutic skills pertinent to HIV/AIDS.