DOI: 10.36347/sjams.2013.v01i04.025

Pages: 310-313

Abstract: LCH is a disorder of unknown cause,characterized by an abnormal proliferation of histiocytes.The disease has a predilection for children,although LCH may occur in adults.The basic histopathological findings are identical in the three well established clinical syndromes (eosinophilic granuloma,Hand-Schuller-Christian disease,Letterer-Siwe disease). Knowledge of the spectrum of clinical features and radiological appearances will facilitate early diagnosis. The radiographic skeletal survey is the cornerstone of the initial imaging evaluation for Langerhans cell histiocytosis because it allows the detection of bone lesions, which occur in most children affected by the disease .To accurately detect Langerhans cell histiocytosis at an early stage, radiologists must recognize the significance of individual clinical and laboratory findings as well as the relevance of imaging features for the differential diagnosis.