DOI: 10.36347/sjmcr.2020.v08i01.005

Pages: 16-18

Introduction: Systemic lupus erythematosus is an autoimmune disease characterized by the presence of antibodies Nuclear. Drug-induced lupus is an ancient, well-known but rare entity. Observation: We report a case of systemic lupus erythematosus induced by The isoniazid. It was a female Patient, elderly of 23 years old who Introduced lupus induced a month and a half after taking anti-bacillary treatment for pulmonary tuberculosis with positive microscopy. The Disease was manifested by a fever, A Skin impairment made of a facial butterfly rash, scaly erythematic lesions and itchy of arms and legs, without joint, renal, cardiac, or neurological damage. Microcytic hypochromic anemia has been associated with it. Anti-nuclear antibodies and native anti-DNA antibodies were Positive in the serum of the Patient while the anti-Sm, The anti-SSa, The Anti-SSb were absent, anti-histone antibodies were not made for lack of means. Stopping the anti-bacillary treatment Allowed the regression of the lesions after 15 days and their disappearance after two months, as well as the regression of the anti-nuclear antibodies rate after 6 months. The reintroduction of it by discarding the Isoniazide, the most incriminating anti-bacillary, was associated to a good clinical as well as biological tolerance. Thus, the diagnosis of isoniazid-induced lupus was retained. Conclusion: Our case strengthens the possibility of occurrence of drug-induced lupus.