DOI: 10.36347/sjmcr.2020.v08i02.012

Pages: 147-149

Antagonism of cholinergic neurotransmission for treating inflammatory skin disease is an underexplored area in medical dermatology. Case reports and anecdotal evidence suggests that botulinum neurotoxins (BoNTs), which inhibit acetylcholine release, may be useful for treating plaque psoriasis. The therapeutic effects of scopolamine occur through antagonism of central muscarinic acetylcholine receptors, the predominate type of cholinergic receptor in the brain. Here we present two patients had been affected by plaque psoriasis for longer than 8 years and had got no benefits from the use of conventional therapies. We describe sustained clearance of plaque psoriasis in the two patients following off-label injections of scopolamine and propofol. Scopolamine and propofol may offer a novel therapeutic approach for treating recalcitrant plaque psoriasis. In this report, we discuss about the application of this method in the treatment of psoriasis.