DOI: 10.36347/sjams.2017.v05i03.049

Pages: 969-974

Dehydroepiandrosterone (DHEA) has been proposed to improve pregnancy rates in women with diminished ovarian reserve undergoing in vitro Fertilisation (IVF) treatment. However, there are limited studies showing its efficacy. So, this study shows the effect of DHEA on ovarian reserve markers. The objectives of this study was to evaluate the effect of dehydroepiandrosterone (DHEA) supplementation on ovarian reserve by measuring markers such as antral follicle count, serum anti-Mu¨ llerian hormone (AMH) and serum follicular stimulating hormone in patients with diminished ovarian reserve. This prospective study was done at sawai man singh medical college, Jaipur. Thirty patients with diminished ovarian reserve were included in the study and received supplementation with DHEA 75 mg OD, for 3 months. Serum AMH, follicle-stimulating hormone (FSH) and antral follicle count were determined before and after DHEA supplementation. Those showing poor response were given DHEA for 6 months. Baseline ovarian reserve parameters such as antral follicle count, FSH, AMH, factors affecting ovarian reserve, and pregnancy rates were studied. There were significant differences in FSH, antral follicle count and AMH levels before and after DHEA supplementation (p < 0.05). The study population was divided into two age groups (<35 and 35 years and above) to determine whether there was a difference in the effect of DHEA supplementation between younger and older patients with diminished ovarian reserve. Significant differences were found in S.AMH and AFC in both study groups (p < 0.05). DHEA supplementation is an effective option for patients with diminished ovarian reserve. Prior to assisted reproductive technology, patients with diminished ovarian reserve should be offered DHEA supplementation as an alternative to oocyte donation.