DOI: 10.36347/sjams.2017.v05i03.081

Pages: 1142-1146

Asthma is a syndrome characterized by airflow obstruction that varies markedly both spontaneously and with treatment. Elevated C-reactive protein is known to be a predictor of adverse events in cardiovascular disease and is increasingly used as a surrogate marker of systemic inflammation in diverse conditions. On the other hand, systematic use of spirometry is critical in assessing the severity of asthma. Worldwide studies show that serum-CRP has negative correlation with spirometric lung function, while few other studies show no significant relation. The objective of the study was to explore whether serum-CRP levels bear any relationship with the severity of bronchial asthma or not. A cross-sectional study has been conducted including total 49 patients of bronchial asthma, of age between 18-65 years and both the sexes attending OPD and ward of Department of Respiratory Medicine, RIMS, Imphal. Computerized spirometry has been used for doing Pulmonary Function Test. For measuring s-CRP, agglutination test using CRP kit has been used. A p-value of <0.5 has been taken as statistically significant. Pearson’s correlation coefficient between prebronchodilator FEV1 and CRP level is -.800, the p value being .01, which means that there is significant negative correlation between prebronchodilator FEV1 (taken in percentage of predicted value) and s-CRP level. As FEV1 value directly indicates the severity of bronchial asthma, s-CRP can be considered as a good predictor of bronchial asthma severity.