DOI: 10.36347/sjams.2017.v05i01.054

Pages: 282-285

Menopause is a natural aging process in women’s life marked by the cessation of ovarian function. The increased incidence of cardiovascular risk in the post-menopausal women may partly be due to hormonal changes leading to derangement of lipid metabolism. The present study is aimed to evaluate the variability of lipid profile in pre- and post-menopausal women. A total of 160 women participants who attended Out Patient Department, RIMS, Imphal were included in the study. Out of which 80 were premenopausal aged 35- 45yrs and 80 were postmenopausal aged 45-60yrs. Serum Total Cholesterol (TC) was determined by enzymatic (CHOD-PAP) calorimetric method, Triglycerides (TG) by enzymatic (GPO-PAP) method, HDL-C by precipitant method and LDL –C by using Friedewald formula: LDL- C = TC − (HDL-C + TG/5) and VLDL= TG/5. Data were analyzed by using SPSS version 21. T test was used to compare means. P value < 0.05 was considered as significant. There were significant increased in serum TC and LDL-C in the postmenopausal women (P<0.05), but HDL-C was found significantly decreased in them (P<0.005). However, there were no significant differences in serum TG and VLDL-C between the two study groups. The elevated serum TC, LDLC and the reduction of cardio protective HDL-C is an indication that menopause is an independent risk factor for developing cardiovascular disease in the post menopausal women.