DOI: 10.36347/sjams.2014.v02i03.018

Pages: 971-975

Oxidative stress might be caused by an imbalance between the production of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or easily repair the resulting damage. Glutathione (GSH) deficiency is related to a number of diseases, including neurodegenerative diseases and peripheral neuropathies. In chemical terms, oxidative stress is considered as a large decrease in the reducing capacity of cellular redox couples including glutathione. The purpose of the present study was to evaluate the role of oxidative stress in patients with neuropathic pain no precise studies carried out demonstrating effect of GSH in neuropathy caused by oxidative stress. Hence this study was done to find correlation of GSH with the progression of peripheral neuropathies. However, there have been may indicate better treatment options. For the determination of GSH, Hb and other indices the blood samples of patients suffering with neuropathic pain were collected from Karachi, Pakistan. The results showed significant difference in GSH levels between normal individuals and in patients with neuropathic pain. These differences were also found significant among the neuropathic pain patients with the history of diabetes and other peripheral neuropathies. In conclusion, the reduced levels of GSH in patients with neuropathic pain may indicate the involvement of oxidative stress which might be more in patients suffering from diabetic neuropathy.