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Scholars Journal of Applied Medical Sciences | Volume-2 | Issue-04
Intranasal Midazolam V/S Intranasal Ketamine as Pre Medication in Paediatric Patients: A Comparative Study
Shreyavathi R, Prabha P, Raghavendra Rao R.S, Aarthi J
Published: July 29, 2014 |
194
129
DOI: 10.36347/sjams.2014.v02i04.019
Pages: 1260-1262
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Abstract
A relaxed and calm child coming into the operating room is a welcome sight and goes a long way to help in
smooth induction, maintenance and also post operative outcome. One of the methods is preanaesthetic medication in
children aiming to relieve the anxiety and to calm the child. This should facilitate induction of anaesthesia without
prolonging the recovery. Intranasal route to administer the premedication is accepted and easy to administer in children.
The aim of our study was to evaluate & compare the efficacy of intranasal Ketamine & intranasal Midazolam as
premedication in paediatric patients. Patients were randomly allocated to two groups of 30 each, receiving intranasal pre
medication, group K received intranasal Ketamine (drops) 5mg/Kg with intranasal Glycopyrrolate 0.2 mg, group M
received intranasal Midazolam (drops) 5mg/kg. Sedation in children was measured using Ramsay Sedation Scale. Both
Midazolam and Ketamine produced rapid and adequate sedation before the child was shifted into the operating room.
Quality of sedation was better with intranasal Ketamine enabling easier parental separation. We found that intranasal
route is a convenient and safe route for premedication in children.