DOI: 10.36347/sjams.2014.v02i04.027

Pages: 1290-1294

The liver as a very important organ plays a central role in energy metabolism in the body. If the liver is impaired it could lead to serious clinical integrations. The study was designed to possibly investigate the effect of boiled Parkia biglobosa at different level of dietary incorporations on the liver and oxidative stress activity using Wistar Albino Rats. Twenty Wistar Albino Rats’ age and sex matched were randomized into four groups. The control group was fed with growers mash, the group labelled A had 5% of Parkia biglobosa incorporated in their diet, the group labelled B had 10% Parkia biglobosa incorporated in their diet while the group labelled C had 20% Parkia biglobosa incorporated in their diet. The animals were fed for a period of 28 days after which they were sacrificed and serum collected from the blood for biochemical estimation. The result from liver function tests shows that there is a significant increase (p<0.05) of ALT, AST, ALP, TB, DB, protein, in the 5%, 10% and 20% as compared to the control. Result from oxidative stress reveals that there is a high level MDA and CATALASE in the 5%, 10% and 20% (p<0.05) as compared to the control. The increase in high level of serum liver enzyme markers observed in the test rats may indicate that Parkia biglobosa exhibited some hepatotoxic effect.