DOI: 10.36347/sjams.2014.v02i04.029

Pages: 1297-1301

Diabetes mellitus (DM) is a metabolic disorder of carbohydrate, fat, and protein characterized by chronic hyperglycemia conditions. Oxidative stress due to hyperglycemia in patients with diabetes may fasten the process of pancreatic tissue damage. Physalis angulata L or Ciplukan herb is one of Indonesian medicinal plants that has been used traditionally and empirically proven as an antidiabetic. Objective the study was determine whether there is a difference between physalin standardized extract from Physalis angulata L and control on pancreatic function of Sprague Dawley rat induced by Streptrozotocin-Nicotinamide. The study was true experimental research design with a post-test only control group design. The subjects of this study were 32 male Sprague Dawley rat induced by Streptozotocin and Nicotinamide. The extract was given a dose of 20 mg / kg for 21 days. At the end of the study, pancreas organs were taken for histological preparations. There were continued by observed of the diameter of Langerhans islets. Normality test data Kolmogorov Smirnof was to determine the differences analysed by t-test. There was a significant difference between the diameter of the islets of Langerhans treatment and control group (p = 0.001). The provision of physalin standardized extract from Physalis angulata L at a dose of 20 mg / kg BW can repair the size of the islets of Langerhans. The treatment can prevent oxidative stress and are able to maintain cell function of pancreas.