DOI: 10.36347/sjams.2014.v02i04.052

Pages: 1402-1407

Myeloperoxidase (MPO), a hemoprotein abundantly expressed by polymorphonuclear neutrophills (PMNs) secreted during activation, possess potent proinflammatory properties and contribute directly to tissue injury. Family history plays an important role in the genetic predisposition of cardiovascular disease (CVD). The influence of MPO - 463 G/A genetic polymorphism on plasma levels and oxidative stress after neutrophill activation was studied. The case control study enrolled 54 control and 161 patients which further divided in three subgroups i.e SAP = 52, UAP = 53 and AMI = 56 respectively. Lipid profile, MDA, Catalase and Plasma MPO were analyzed by established techniques. Genotypic analysis of -463 G/A MPO was undertaken by PCR. Data suggest that the GG genotype occurs frequently in patient subgroups (SAP = 57.69%, UAP = 66.04% & AMI = 64.2%) compared with controls (51.85%). The plasma MPO levels in GG, GA and AA genotype of control with UAP and AMI subgroup have shown significant correlation (p < 0.05) whereas a non-significant (p > 0.05) association was observed in SAP subgroup. Study concluded that there is significant indirect association of GG genotype (with respect to AA genotype) in -463 G/A MPO genetic polymorphism in SAP, UAP and AMI subgroups respectively.