DOI: 10.36347/sjams.2014.v02i04.055

Pages: 1416-1421

The traditional risk factors for coronary heart disease do not account for the entirety of risk and there are many people who have events and do not fit into these traditional risk factors. The aim of the study was to assess multiple biomarkers representing in relation to cardiovascular events and to evaluate the levels of HbA1c, sialic acid, Homocysteine, high sensitive C–reactive protein in non-diabetic individual with acute myocardial infarction and possibility of their use as markers for coronary vascular events. Total 600 patients were included in the study and were divided into two groups: Group-I (cases): 300 clinically diagnosed non-diabetic myocardial infarction patients admitted in Emergency and ICCU wards. Group-II (controls): age and sex matched 300 healthy subjects with no history of diabetes mellitus and/or myocardial infarction were included. The blood samples were collected from all the cases and the control and were immediately analyzed for biochemical parameters under the study. The result indicates that there is a statistically significant increase in Systolic-BP, Diastolic-BP, fasting blood glucose, HbA1c, LDL-C, sialic acid, homocysteine and Hs-CRP levels in cases as compared to control group (<0.001). Also, there is a direct and significant correlation between sialic acid with homocysteine, Hs-CRP and HbA1c respectively (r =0.24, 0.24, 0.30,p<0.05). HbA1c showed significantly positive correlation with homocysteine, Hs-CRP and Diastolic-BP (r = 0.27, 0.24 and 0.19) respectively and had negative correlation (r = -0.20) with HDL-C.