DOI: 10.36347/sjams.2014.v02i05.034

Pages: 1660-1662

Human cytomegalo virus (CMV) is a double stranded DNA belongs to Herpesviridae family that is restricted to humans. CMV can be transmitted from infected to non infected individuals through various types of body fluids; the infection can also be transmitted from infected women to her fetus during pregnancy. The prevalence of congenital CMV infection ranges from 0.3 to 2.3% of live births in different populations. A high prevalence of CMV infection was demonstrated among pregnant women in Sudan. The aim of the current study was to screen the presence of CMV IgG and IgM in Sudanese children with congenital malformation. It was a descriptive, cross sectional study performed in the period between May and July 2014 at Academy charity hospital, Sudan. 90 of Sudanese children with congenital malformation (46 male and 44 female) were included in this study. The patients were classified into three age groups: below 2 years, between 2 and 4 years and more than 4 years. Questionnaires were used to collect the patients' data. The IgM and IgG antibodies against CMV in patients' samples were detected by using ELISA technique. The results showed that 93.3% of the patients were seropositive for CMV IgG, and 90% of them had CMV IgM in their serum. The major malformation observed among patients was hydrocephaly (46.7%), microcephaly was observed in only 5.6% of the patients. (71.1%) of the tested malformation child mothers had history of abortion; 93.8% of their child had CMV IgG. Human cytomegalo virus (CMV) infection was frequent among Sudanease patients with congenital malformation, especially in the age group below 2 years.