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Scholars Journal of Applied Medical Sciences | Volume-2 | Issue-06
JAK2 V617F Mutation in a Patient With Adrenal Incidentaloma and Essential Thrombocythemia
Ferhat Ekinci, Utku Erdem Soyaltın, Tuba Demirci Yıldırım, Hamiyet Yılmaz Yaşar, Harun Akar
Published: Nov. 28, 2014 |
186
163
DOI: 10.36347/sjams.2014.v02i06.021
Pages: 2053-2055
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Abstract
A 62-year-old woman is incidentally found to have adrenal mass, 24*15 mm in diameter, on abdominal
computed tomography for evaluation of acute arterial occlusion. Biochemical screening was negative for a functioning
adrenal tumor. Routine blood works were significant for a platelet count of 572.000/mm3. Platelet counts were measured
again and it’s found as 1.080.000/ mm3. The JAK2 V617F mutation was positive which investigated for the etiology of
thrombocytosis. Inappropriate JAK2 signaling causes the survival of some solid tumors and cell proliferation. Our case is
the third coexistence of the JAK2 V617F mutation with essential thrombocytosis and non-functional adrenal
incidentaloma.