DOI: 10.36347/sjmcr.2020.v08i03.025

Pages: 348-351

Primary mediastinal large B-cell lymphoma (PMBCL) is a distinct entity within B-cell lymphomas (2–4% of non-Hodgkin lymphomas). It occurs most frequently in young females but rarely during pregnancy. Moreover, a cardiac tamponade is unusually found in pregnant women. We describe a case of a 32-year-old woman, 16-week pregnant, with cardiac tamponade revealing PMBCL, where urgent pericardiocentesis was required to maintain maternal cardiac function. An MRI (Magnetic Resonance Imaging) revealed a huge mediastinal mass of which biopsy confirmed the diagnosis of a PMBCL. A spectacular improvement of the clinical signs was obtained after a first line chemotherapy including rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Our patient received the entire chemotherapy during her pregnancy with a regular multidisciplinary follow up. PMBCL can expose pregnant women to cardiac tamponade, and physicians should be aware of this complication mainly when pericardiocentesis is necessary.