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Scholars Journal of Applied Medical Sciences | Volume-2 | Issue-06
Plasma Total Antioxidant Activity and Endothelium Dysfunction in Hypertensive Smokers
Jusmita Dutta, Dilutpal Sharma, Rahul Saxena
Published: Dec. 29, 2014 |
183
116
DOI: 10.36347/sjams.2014.v02i06.097
Pages: 3345-3348
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Abstract
Although role of oxidative stress in the etiopathogenesis of hypertension (HT) development has been well
documented, there is no far conclusive evidence regarding alteration in plasma total antioxidant activity (TAA) and nitric
oxide (NO) levels in hypertensive smokers. Aims & objective of the study was to ascertain the plasma TAA, NO, uric
acid and erythrocyte malondialdehyde (MDA) in normotensive and hypertensive smokers, and to determine their
cumulative effect in disease pathology. Plasma TAA, NO, plasma uric acid and erythrocyte MDA levels were estimated
in 120 subjects (30-55 years), categorized into three groups (40 subjects in each group) depending upon their smoking
habit and blood pressure i.e. Healthy non smokers (Control group), normotensive smokers (Group I) and Hypertensive
smokers (Group II); and compared it statistically by using student’s t- test. Plasma TAA and NO levels were significantly
low (p<0.05, p< 0.001) in Group I and II, as compared to healthy controls where as plasma uric acid levels were
increased insignificantly (p<0.1) in Group I and significantly (p<0.05) only in Group II. On the other hand, erythrocyte
MDA levels were significantly high in both the study groups with respect to controls. Alteration in plasma TAA and uric
acid along with endothelial dysfunction due to culprit effect of oxidative stress (via MDA production) may be
responsible for development of HT in smokers. Therefore, change in dietary pattern and community based preventive
approach should be encouraged in order to overcome the burden of hypertension as well as harmful effects of smoking.