DOI: 10.36347/sjams.2014.v02i06.120

Pages: 3438-3444

The aims and objective of the study were to compare the efficacy of inj. Pethidine and inj. Butorphanol in preventing post-operative nausea and vomiting and to compare better analgesic as premedicant in patients undergoing laparoscopic cholecystectomy.50 patients aged from 20 – 70 years of ASA –I &II physical status under going laparoscopic cholecystectomy were included and were divided into two groups; group I (25 patients) received Pethidine 0.5 mg/Kg body weight and group II (25 patients) received Butorphanol20 mcg/Kg intravenously 10 minutes before the induction of anaesthesia. Postoperatively the patients were assessed for vital signs, pain, nausea, vomiting. The patients selected in both the groups are comparable, in terms of age, weight, technique of anaesthesia, and surgical procedure. Post operatively there was no significant difference in the pulse rate, BP, RR, VAS between the two groups. The incidence of nausea was significantly higher in patients who received Pethidineas compared to Butorphanol (p < 0.05). Similarly the incidence of vomiting was high in Pethidine group that is seven patients experienced vomiting compared to two patients in Butorphanol group which is statistically significant (p < 0.05). The time of first rescue analgesic was longer in patients of Butorphanol (205 + 60 mins.) as the pre-medication drug compared to the Pethidine (170 + 40 mins.) and it was supplemented with inj. Tramadol (0.5 mg / kg body wt.). Eight patients in Butorphanol group had more drowsiness than four in Pethidine group, one hour after the admission to recovery room. However there was no episode of Hypoxemia (SPO2 < 90%), respiratory depression (RR< 8 / min.) in any of the patient. In conclusion, Butorphanol decreased the nausea, vomiting episodes, and provided a better control of pain in the postoperative period than Pethidine.