DOI: 10.36347/sjams.2017.v05i02.013

Pages: 369-372

Urinary tract infections is one of the most frequent infections that occurs worldwide. Diabetes mellitus has deleterious effects on the genitourinary system that renders Diabetic patients more vulnerable to UTI. Fluroquinolones are widely used class of antimicrobial agents for the treatment of UTI. The study is aimed to validate the different uropathogens in patients with DM and their susceptibility or resistance to quinolones. The study population comprised of a total of 200 diabetic patients with UTI. Identification was done by gram staining, culture methods and biochemical tests. Antibiotic susceptibility test to the selected quinolones was done by using Kirby Bauer’s Disk Diffusion method according to CLSI guidelines. Out of a total of 200 samples growth was seen in 130 samples. Different bacterial pathogens according to the prevalence were E.Coli (32) ,Staphylococcus aureus (16), Klebsiella(12), Pseudomonas aeruginosa(11), Proteus species(10), Enter. ococcus species (8), Acinetobacter species (5), Enterobacter (5), Citrobacter(6), Serratia (2), Candida albicans (18) and Candida non-albicans(5). Susceptibility of quinolones is as follows, Norfloxacin (68%), Naldixic Acid(58.4%), Ciprofloxacin(63%%), Levofloxacin(75.3%) , Gatifloxacin(83%), Ofloxacin (72%) and Moxifloxacin (89%) respectively. There is an alarming increase in prevalence of resistance to Fluroquinolones among the diabetic patients with UTI. From our study results we conclude that quinolones should be prescribed after doing the antibiotic susceptibility testing that will prevent the extensive and unnecessary use of antibiotics and so the emerging resistance.