DOI: 10.36347/sjams.2017.v05i02.020

Pages: 401-406

Resistant bacteria are emerging worldwide as a threat to the favourable outcome of common infections in community and hospital setting due to widespread use of 3rd generation cephalosporins. Infections due caused by extended spectrum beta lactamase (ESBL) producing organisms have markedly increased the rates of treatment failure and death. Our aim was to study clinical profile of septicemia due to ESBL producing organisms. All cases with septicemia and blood culture positivity due to ESBL producing organisms were recruited. This study was conducted over a period of 2 years. Total 58 patients were included with mean age of 48.93years. The most common source of sepsis was from urinary tract 67.3% and most common organ dysfunction observed was Renal77.6% followed by hepatic 34.8% Respiratory dysfunction 31.1%. DIC24.1% and shock13.8%. Presence of four /more organ dysfunction was significantly with mortality/and among 58 patients, 12 patients expired. Main independent predictors of mortality were APACHE II score >25, presentation with septic shock and presence of organ dysfunctions. Carbapenems were drugs with highest sensitivity 100%, followed by Amikacin and, Pipercilin tazobactum.