DOI: 10.36347/sjams.2017.v05i02.042

Pages: 517-522

Postoperative pain management has become a challenge as no drug has been found to be ideal. Many authors have studied the effect of neuropathic pain killer like pregabalin as preemptive analgesic for management of acute postoperative pain. The dose of preemptive pregabalin for the same has not yet been optimized. The present study has been undertaken to find out optimal dose of pregabalin as pre-emptive analgesic. It was a randomized double blind prospective study with 80 patients of American society of anaesthesiology (ASA) Grade I and II, aged between 30 to 65 years. All patients were divided into 4 groups with Group M7.5 received 7.5mg midazolam, Group P75 received 75mg pregabalin, Group P150 received 150mg pregabalin and Group P300 received 300mg pregabalin orally. VAS score, total dose of rescue analgesic and hemodynamic was compared in all 4 groups. VAS was significantly low in group P300 and group P150 than group I and II. The total dose of nalbuphine consumed in 24 hours duration was significantly less in group P300 and group P150 than group M7.5 and P75. Sedation scores were more in patients of group P300. Side effects like dizziness were more in Group P300 than other groups. Preemptive oral pregabalin 300mg is most effective in providing good postoperative analgesia compared to other doses but has side effects like dizziness. So pregabalin 150 mg may be ideal instead of 300mg.