DOI: 10.36347/sasjm

Pages: 61-65

Among the microvascular complications of type 2 diabetes mellitus, second most common complication is diabetic nephropathy (after retinopathy). Overt dyslipidemia may aggravate the condition, and it is also known to increase the risk of cardiovascular diseases (CVDs). The present study included 110 type 2 diabetic individuals each with and without nephropathy and 110 age and gender matched healthy non-diabetic individuals. The concentrations of FBG, HbA1c, TC, TGs, and high density lipoprotein cholesterol (HDL-C) were estimated from fasting blood samples. Significant increase was found in BMI, FBG, HbA1c, TC, TGs, LDL-C, VLDL-C, serum urea and creatinine in type 2 diabetic patients with as well as without nephropathy as compared to healthy individuals, while HDL-C was significantly decreased. The increased levels of urine creatinine and higher albumin/creatinine ratio were observed in type 2 diabetic nephropathy subjects as compared to healthy controls. Patients with proteinuria had significantly higher BMI, TC, TGs, LDL-C, VLDL-C, Serum urea, serum creatinine, urine creatinine, microalbumin, and albumin/creatinine ratio when compared to the patients with microalbuminuria. Hence, lipids and lipoproteins along with stage of nephropathy should be considered for prediction of CVDs in type 2 diabetic subjects with & without nephropathy